Up from the depths of the Hollow Earth to the parched Arizona deserts and into the Twilight Lands, Lone Crow with his trusty Peacemaker pistol, blessed by the hand of a prophet, battle against prehistoric creatures, supernatural menaces, and even a twisted version of himself.

Along the way, he joins forces with the infamous Mormon gunfighter Porter Rockwell, the wild-haired pistolera Six-Gun Susannah Johnson, and his former enemy, the inimitable Isidro Acevedo in order to hunt down man-killers, demons, and malevolent deities.